3 One Health AMR
Read the full chapter about One Health AMR here
Report Highlights 2023:
One Health AMR
DANMAP was established with the aim of understanding the drivers of antimicrobial resistance in humans and in the livestock industry and their interconnectedness. The monitoring programme has always been considered an integrated approach to research and surveillance.
To be able to foresee if changes in one sector will have a possible significant impact on the other sector, it requires knowledge of the probable routes of transmission and the size and speed of transfer. Several recent studies report possible zoonotic transmission of extended spectrum beta-lactamase-producing E. coli (ESBL Ec), underlining the importance of monitoring the occurrence of these bacteria in animals and humans, and assessing the possibility of transfer across sectors.
Here we cross-analyse antimicrobial resistance data from monitoring in livestock animals and humans in Denmark. We map the frequency of multi-locus sequence types (MLST) and resistance genes and mutations of ESBL Ec from livestock animals and meat and from humans with bloodstream infections. Furthermore, we study the genomic context of selected resistance genes detected in those isolates, which may have been horizontally transferred between reservoirs.
In this chapter, we demonstrate, as previously done, possible relationships between ESBL Ec from different sources in Denmark, and we furthermore deepen the genomic analyses to further investigate the possible occurrence of zoonotic transmission.